BC 02. Impact of Sarcopenia on Outcomes Following Resection for Perihilar Cholangiocarcinoma
R. Coelen, J. Wiggers, C. Nio, M. Besselink, O. Busch, T. van Gulik
Chair(s): Mustafa Cikirikcioglu, Frank Dor, René Tolba, David J. Hackam, Cliff Shearman, Modise Koto
13:40 - 13:50h
at Erszebet Room (A)
Categories: ESSR Best Clinical Research Paper, Hepatobiliary and Pancreatic Surgery
Session: ESSR Best Clinical Research Paper
Invited discussant: Osman Yuksel, Attila Szijártó, Lázár György, Gokhan Yagci, Mihály Boros, Thomas Hubert
Background Loss of skeletal muscle mass, sarcopenia, reflects the frailty status of patients and has recently been associated with worse outcomes following surgery for malignancies of gastrointestinal origin. The aim of this study was to investigate the impact of sarcopenia on morbidity and survival following resection for perihilar cholangiocarcinoma (pHCCA).
Material and Methods
Data were retrospectively collected from a prospectively maintained database containing all patients in our institute undergoing resection for suspected pHCCA between 1992 and 2013. Sarcopenia was assessed by measuring total skeletal muscle mass at the level of the third lumbar vertebra on preoperative computed tomography images. Internationally accepted cut-off values (52.4 cm2/m2 for men, 38.5 cm2/m2 for women) were used to assign patients to either a sarcopenic or nonsarcopenic group. Clinicopathological data, postoperative morbidity (Clavien-Dindo grade 3 or higher) and long-term survival were analysed.
Result
Sarcopenia was present in 56 (65%) of 86 patients and was significantly associated with male sex and lower body mass index. Overall postoperative complication rate (Clavien-Dindo ≥ 3) was similar in both groups (55% vs 53%, p=0.86) and no significant difference was seen in in-hospital mortality. On univariate analysis sarcopenia was associated with overall survival (p=0.04, log rank test). When corrected for resection margin- and lymph node status, the prognostic effect of sarcopenia on overall survival did not reach significance (p=0.07).
Conclusion
The prevalence of sarcopenia in pHCCA is high. A trend in prognostic effect of sarcopenia on overall survival following resection was noted.
