PP 45. Peritumoral Vascular and Lymphatic Invasion in Breast Cancer

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N. Salemis, G. Karavitis, N. Koronakis, E. Lagoudianakis, G. Karanikas, A Papas, A Manouras, G. Zografos

18:10 - 18:16h at Lanchid Room

Categories: Poster Session , Surgical Oncology

Session: Poster (P4) - Surgical Oncology

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Background
Peritumoral vascular (PVI) and lymphatic invasion (PLI) may signal an increased metastatic potential. The aim of this study was to correlate PVI and PLI of invasive ductal carcinoma with stage and prognosis.

Material and Methods
We analysed the medical archives of 236 female patients with invasive breast carcinomas, with a mean age of 60 years old (SD± 15.1 years). Prognosis data were acquired from 93 patients of the cohort.

Result
Pathological examination revealed that 22.5% of the patients had vascular vessel infiltration and 37.3% had lymphatic vessel infiltration at the invasive tumor front. Statistical analyses showed that vascular vessel infiltration correlated with advanced TNM stage (p<0.05), higher T stage (p<0.05), higher N stage (p<0.05). In a similar manner lymphatic vessel infiltration correlated with advanced TNM stage (p<0.05) , higher T stage (p<0.05) and higher N stage (p<0.05). The median follow-up of our patients was 30 [22.46] months. During this period of follow-up 13.2% had disease recurrence and 6.5% died. The statistical analysis did not showed significant correlation between the presence of infiltration of the vascular and the lymphatic bed in the periphery of the tumor and the overall and disease-free survival.

Conclusion
The presence of PVI and PLI correlates with advanced stage of the disease but lacks prognostic significance.