PP 46. EGFR Expression Correlates with Advance Stage and Grade in Breast Cancer

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N. Salemis, G. Karavitis, N. Koronakis, G. Karanikas, A Papas, A Manouras, G. Zografos, E. Lagoudianakis

18:16 - 18:22h at Lanchid Room

Categories: Poster Session , Surgical Oncology

Session: Poster (P4) - Surgical Oncology

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Background
EGFR has been associated with unfavourable prognosis in patients with triple-negative breast carcinomas. The aim of this study was to investigate the expression of EGFR and its correlation with stage, grade and prognosis in an unselected cohort of Greek patients with breast cancer.

Material and Methods
We analyzed the medical archives of 306 female patients with invasive breast carcinomas, with a mean age of 56 [45-68] years.

Result
Immunohistochemical analysis revealed that 17% of the patients were positive for EGFR expression. Statistical analyses showed that EGFR positive tumors correlated with higher histologic grade (p<0.05) and advanced TNM stage (p<0.05). Marginal statistical association was found between EGFR expression and size (p=0,06) and lymph node metastasis (p=0,08) The median follow-up of patients was 63 [61,66] months. During follow-up of patients 14.8% had disease recurrence and 19.5% died. Adjusting for stage and grade EGFR expression showed statistically significant relationship with survival (Exp (B) = 2,05, p = 0,03) and disease-free survival (Exp (B) = 4,16, p = 0,001)

Conclusion
These data indicate that EGFR is a prognostic factor of worse clinical outcome and that the EGFR positive phenotype is associated with advance stage in breast cancer patients.