PP 57. Immunohistochemical Expression of Nek6 and Its Predictive Value for Cancer Progression in Endoscopically Resected Early Colorectal Carcinomas

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M. Sook Roh, S. Yeon Ha, Y. Roh

19:22 - 19:28h at Lanchid Room

Categories: Poster Session , Surgical Oncology

Session: Poster (P4) - Surgical Oncology

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Background
Endoscopic resection could be a curative treatment for low-risk early colorectal carcinoma. If we can forecast the likelihood of cancer progression of early colorectal carcinoma, we should be able to establish improved indications for appropriate treatment modality for early colorectal carcinoma. Nek6 is a serine-threonine kinase belonging to the Nek (NIMA-related kinase) family, which could promote cell transformation and cancer progression by inhibiting the onset of cellular senescence.

Material and Methods
We analyzed 94 lesions of early colorectal carcinoma confined to the mucosa (40 cases) and submucosal invasion (54 cases) to evaluate correlations between immunohistochemical expression of Nek6 and clinicopathological factors.

Result
Nek6 immunoreactivity was significantly higher in carcinoma with submucosal invasion (8/54; 14.8%) than in intramucosal carcinoma (1/40; 2.5%) (P = 0.049). With respect to depth of submucosal invasion, Nek6 immunoreactivity was significantly higher in carcinomas with submuosal invasion of ≥ 1000μm (6/22; 27.3%) than in carcinomas with submucosal invasion of < 1000μm (2/32; 6.3%) (P = 0.047). Of 54 carcinomas with submucosal invasion, lymph node metastases were found in four cases (7.4%), all of which showed Nek6 immunoreactivity.

Conclusion
A subset of early colorectal carcinoma revealed Nek6 immunoreactivity, and this was associated with invasion depth and lymph node metastasis. Our data suggest that Nek6 may play a role in tumor progression of early colorectal carcinomas, therefore, Nek6 expression could be potentially useful predictive marker for estimating cancer progression of early colorectal carcinomas.