PP 58. The Relationship of PTEN and NEDD4-1 in Non-Small Cell Lung Cancer

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S. Yeon Ha, M. Sook Roh, A Hi Lee

19:28 - 19:34h at Lanchid Room

Categories: Poster Session , Surgical Oncology

Session: Poster (P4) - Surgical Oncology

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Background
Loss of the PTEN gene occurs frequently in non-small cell lung carcinoma (NSCLC). There is a report NEDD4-1 is a PTEN negative regulator. We evaluate the correlation of NEDD4-1 and PTEN in NSCLC.

Material and Methods
There were 241 patients diagnosed as NSCLC between 2000 and 2010. We analyzed 201 cases that were classified as adenocarcinoma and squamous cell carcinoma. Immunohistochemical staining for PTEN and NEDD4-1 with clinicopathologic characteristics was performed.

Result
Loss of PTEN was under 55 years old (65.5%, p<0.05). In squamous cell carcinoma, loss of PTEN was detected 65.9% and overexpression of that was 34.1%. Overexpression of NEDD4-1 was 70.3%. In adenocarcinoma, 51 cases (46.4%) were weak staining for PTEN and 60 cases (54.5%) were strong expression for NEDD4-1.

Conclusion
Overexpression of NEDD4-1 was correlated with loss of PTEN in squamous cell carcinoma. However that was not relationship in adenocarcinoma. In this study, overexpression of NEDD4-1 associated with loss of PTEN could be helpful to make a differential diagnosis.