PP 67. Comparison of Anatomical and Nonanatomical Hepatic Resection for Solitary Hepatocellular Carcinoma -A Case-Controlled Study with Propensity Score Matching-
Y. Okamura, T. Sugiura, T. Ito, K. Uesaka
18:52 - 18:58h
at Lanchid Room
Categories: Poster Session
Session: Poster (P5) - Hepatobiliary & Pancreatic Surgery
Background
It remains controversial whether anatomical resection (AR) improve the prognosis for hepatocellular carcinoma (HCC) or not. However, there has been never reported even a well-matched study about this issue. The aim of the present study is to compare the recurrence-free survival of AR versus nonanatomical resection (NAR) for HCC using propensity score matching.
Material and Methods
The present study intended for 236 patients with a solitary tumor, and without macroscopic vessel thrombosis. Those patients were divided into AR (n=139) and NAR (n=97) groups. Propensity score matching was performed to minimize the effect of potential confounders.
Result
A total of 64 patients from each group were matched. Preoperative confounding factors were wellmatched between the two groups. No difference was detected in the recurrence-free survival rates between two groups (P = 0.520). There was no significant difference in recurrence pattern between these two groups (P = 0.254). Multivariate analysis revealed that AFP > 20 ng/mL (Hazard Ratio [HR] 2.73, P < 0.001), the presence of microsatellite lesions (HR 2.32, P = 0.044), and positive for HCV-Ab (HR 1.84, P = 0.029), remained as significant independent predictors for recurrence. Operative procedure was not significant risk factor for recurrence in both of uni- and multivariate
analyses.
Conclusion
This first case-matching study using propensity score shows that there is no superiority of AR relevant to the recurrence-free survival compared with those of NAR in cases with a single HCC.
