Background
Tissue replacement is one of the most important areas of novel biomedical researches. Implanting artificial meshes into living organisms, to provide adequate surface for tissue regeneration, makes great demands on the material and structure of the biopolymer itself. The main requirements for applying artificial polymer matrices are to be biocompatible and biodegradable, as well.

Material and Methods
Electrospinning technique was used for producing polymer fibers to evolve an artificial ECM (extracellular matrix)- like scaffold. In order to avoid rapid dissolution of the fibrous polymer in biological fluids, PSI (poly(succinimide)), which is the anhydrous form of poly(aspartic acid), was cross-linked. For testing biocompatibility HT-1080 (human fibrosarcoma) and HDFa (human dermal fibroblast, adult form) cell lines were studied for 72h in vitro. In parallel, four-week period in vivo experiments were also performed on albino rabbits.

Results
According to our short-termed observations, biocompatibility and biodegradability of poly(succinimide) were suggested. The poly(succinimide) meshes were completely disappeared within 72h in vitro and eleven days in vivo.

Conclusion
Due to biological, chemical, mechanical properties of poly(succinimide) based polymers, poly(succinimide) could be a promising biomaterial for widespread biomedical application.