Background
The swine model is a well-characterized large animal model suitable for experimental studies on short bowel syndrome (SBS). In the literature the extent of intestinal resection to induce SBS in pigs ranges from 75% to 100%. No comparative data is available on the most suitable extent of resection. This study aimed to determine the impact of range of resection of the three main SBS models published on outcome parameters.

Materials and Methods
A 75%-90%-100% mid-intestinal resection was performed in n=5 pigs each. Clinical, biochemical, functional and histological parameters were determined. The observation period was 2 weeks.

Results
Persistent weight loss and diarrhea were present only in the 100% group. Electrolytes levels remained physiological, serum albumin and cholesterol decreased and total protein and triglyceride values increased in all groups (p>0.05). Citrulline values settled at different levels (p<0.05), while D-xylose resorption increased in all groups (p>0.05). Mean intestinal villus- length decreased during observation time (p<0.05 for 100% and 75% group). Levels were higher and changes more prominent in the 75%, followed by 90% and 100% group.

Conclusion
The 75% model is less suitable as SBS model in swine, as animals tend to normalize parameters remarkably. We suggest to resect at least 90% to induce more prominent changes. The 90% is suitable for longer term studies, as partial compensation occured, and animals might therefore survive longer. Due to severe nutritional, biochemical and physiological derangements, the 100% model can be used toward more acute experiments and those immediately followed by small bowel transplantation.