Background
Perfluorocarbon emulsions are blood substitute solutions with anti-ischemic and gas transport properties, they stimulate tissue growth and strengthen reparative regeneration. One of the major components of the pathology of Acute Necrotizing Pancreatitis (ANP) is the impaired microcirculation and the subsequent development of ischemic processes with the activation of anaerobic glycolysis and lipid peroxidation which leads to necrosis.

Objectives
The aim of this study is to investigate the effects of Perftoran: the Russian preparation of the group of Perfluorocarbon (PFC) emulsions on the course and outcome of ANP

Materials and Methods
Rats were divided into 4 groups, the 1st group included rats with surgically modeled ANP (upper-median laparotomy with a 1.5 minute cold exposure of the splenic segment of the pancreas), the 2nd group included rats with perftoran administered intraperitoneally at a dose of 0.5ml per 100g for a period of 5 days after surgically induced ANP, the 3rd group included rats who were performed just upper-median laparotomy, the 4th group included intact rats .The following parameters were investigated during the experiment: The mortality rate, morphological state of the pancreas, vital organs and immune system after the administration of Perftoran.

Result
The use of PFC Emulsions on experimental ANP in rats resulted in decreased mortality rate, reduced necrobiotic and necrotic process in the parenchyma and stroma of pancreas. PFC emulsions improve the reparative regeneration of epithelial and connective tissue structure, restoration of microcirculatory blood vessels and lymphatic flow.

Conclusion
The experiment demonstrates that PFC emulsions are suitable for the treatment of ANP.