PP 134. Effects of Laparoscopic Sleeve Gastrectomy on Type 2 Diabetes And Nonalcoholic Fatty Liver Disease

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A Sasaki, H. Nitta, K. Otsuka, T. Obuchi, S. Baba, A Umemura, T. Iwaya, S. Nishizuka, K. Koeda, M. Mizuno, G. Wakabayashi

17:48 - 17:54h at Lanchid Room

Categories: Endocrine Surgery, Poster Session

Session: Poster II (P4) - Varia

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Background
The aim of the present study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG) on type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD).

Material and Methods
Between June 2008 and January 2014, 31 Japanese patients with severe obesity underwent LSG. Fifteen patients had T2DM; 12 patients were taking oral hypoglycemic agents, and 6 patients were eceiving insulin treatment. All patients underwent computed tomography before and 6 months after LSG, and visceral adipose tissue (VAT) and liver volume were analyzed. The data collected included patient demographics, clinical outcomes, and metabolic and inflammatory parameters.

Result
The mean postoperative excess body weight loss at 1 and 3 years after LSG was 56% and 81%, respectively. Complete remission of T2DM was achieved in all 15 patients at 1 month after LSG.  eak GLP-1 and insulin levels during a 75 g oral glucose tolerance test increased significantly at 1 and 6 months after LSG, respectively. The mean liver volume was significantly decreased at 6
months after LSG (2,301 vs 1,746 mL, p=0.006), and the grades of steatosis and hepatic inflammation in the 5 NASH patients were all reduced. In the T2DM patients, the reduction in VAT was found to correlate with the changes in high-sensitivity C-reactive protein (p = 0.006) and the HOMA-IR (p = 0.001).

Conclusion
The effects of the surgery on body weight and metabolic function indicate that LSG may be a part of the treatment strategy for T2DM and NAFLD.