OP 52. Experimental Parathyroid Autotransplantation in Hypoparathyroidism


M. Erikoglu, B. Colak, H. Toy, M. Gurbilek

17:20 - 17:30h at Buda Room (B)

Categories: Endocrine Surgery, Oral Session

Session: Oral Session VI - Endocrine Surgery


Background:
In this experimental study using rats with hypoparathyroidism, our aim was to investigate whether the excised parathyroid tissue seeded in the liver and in the peritoneum, instead of the SCM muscle.

Material and Methods:
In our study, four different groups, each consisting of 10 Wistar albino rats were used. Group 1 (Sham group): Parathyroid exploration only was made. Group-2 (SCM group): Parathyroidectomy was performed and the parathyroid tissue was seeded into the sternocloido mastoid muscle. Group-3 (Liver group): After parathyroidectomy, laparotomy was performed and the parathyroid tissue was seeded in the liver. Group-4 (Periton group). After parathyroidectomy, laparotomy was performed and the parathyroid tissue was seeded in the peritoneum. After 14 days, the rats were sacrificed and parathyroid hormone was measured, the parathyroid tissue was then excised and examined.

Result:
When we compared group 1 with the other groups, a difference was observed in the levels of PTH hormone (p <0.01). There was no such difference between groups 2 and 3 (p> 0.01). Similarly, there was no significant difference between Group 3 and 4 (p> 0.01). In pathological examination, tissue loss, calcification, necrosis, foreign body reaction and fibrosis, there was no difference between Group 2 and Group 3 (p> 0.01), Likewise, there was no difference between Groups 2 and Group 4 (p> 0.01).

Conclusion:
As a result, it was concluded that during thyroid surgery, the excised parathyroid tissue, in selected cases, may be planted in the liver and peritoneum.