Background:
The objective of the current study was to assess body fat distribution, lipid profile, and leptin changes on an obese minipig subjected to a Roux-en-Y gastric bypass.

Material and Methods:
9 obese minipigs were enrolled in this study. Obesity was developed after a nine-month period of high-fat diet. Then, minipigs were subjected to a laparoscopic RYGBP. The procedure was accomplished laparoscopically by a 5-port approach.
The parameters recorded were body weight, adipose tissue distribution, lipid profile, and plasmatic concentration of leptin. They were measured one week before surgery (T0) and 4 months after surgery (T1). Adipose tissue distribution (VAT –visceral adipose tissue- and SAT. subcutaneous adipose tissue-) was quantified with magnetic resonance imaging scan (MRI). Differences between time points were checked with a paired T-test. A p < 0.05 was considered significant.

Result:
SAT increased after surgery (1032.9 ± 387.72 vs 1360.44 ± 492.26, p=0.051), whereas visceral adipose tissue decreased significantly (1311.01 ± 420.75 vs 672.74 ± 180.32, p=0.01). Regarding lipid profile, total cholesterol (92.89 ± 9.73 vs 76.22±13.05 UI/L, p=0.09) showed a significant decrease. Regarding correlation, body weight was positively correlated with SAT (r2=0.689, p=0.002) and negatively correlated with leptin (r2=0.591, p=0.02).

Conclusion:
These results demonstrate that the altered gastrointestinal anatomy caused by RYGBP provokes changes in the energy metabolism as evidenced by the variation of the distribution of adipose tissue, although the insignificant changes on body weight