Background:
Surgical procedures frequently cause adhesion formation. The consequence is infertility, motility disorders and pain. The development of adhesions is an aquired property which results in pathological alterations. One of the key molecules is plasminogen activator inhibitor-1 (PAI-1).

Material and Methods:
90 male Wistar rats were used for creating an animal adhesion model. 16 animals consisted the control group. In 74 operated animals a part of the parietal peritoneum was removed. The serosal surface of coecum was incised. The injured surfaces were desiccated. The operated animals were divided into eight groups depending on the length of postoperative (po) period. Then localization, extension and stabilization of adhesions was determined. Tissue samples were taken to follow-up cellular events and PAI-1 presence.

Result:
Large-surface cohesive and columnar adhesion was the most frequent type. Stabilized adhesion appeared on the 3rd po. day and there number and proportion increased with comparison to the instabil or moderate stabil types. On the 7th day all of the adhesions were stabilized.
In the early po. period damaged muscle fibres and invanding neutrophil granulocytes could be observed. From the 3rd po. day active fibroblast and endothel cells appears. Histological findings showed ‘unifying’ process, but in stabilized adhesion the original borders of the tissues could’nt be detected. Nerve fibres and PAI-1 molecules were present in the adhesion tissue.

Conclusion:
Regarding the stabilization process and the presence of PAI-1, the best way for prevention of adhesion formation could be discovered.