Background:
Morbidity and mortality rates associated with complicated Intra-abdominal Infections remain exceedingly high. Source control and appropriate use of empirical antibiotics are cornerstones of early management. Selection of empiric antibiotics depends upon microbiological profile and resistance patterns of commonly encountered organisms in hospital and community. In developing countries, data sources are limited to guide selection empiric antibiotics. Use of empirical regimens in this scenario can result in either under treatment or unnecessarily broad coverage. Objective of our study was to find out frequency of various micro-organisms and their resistance patterns to help decide empiric antibiotics in complicated intra-abdominal infections.

Material and Methods:
We conducted review of medical records of patients admitted in last three years from Jan 2011 to Dec 2013. Adult patients of age > 16 years, who were admitted with complicated intra- abdominal infections were included in the study. Data regarding their demographics, clinical presentation, source of infection, culture reports was collected .

Result:
Mean age of 317 patients included in the study was 51+18 years. Common sources of infection were biliary (30%) and large bowel (22.7%). Common organisms reported were E. Coli (56.2%), Enterococci (28.4%) and Klebsiella Pneumoniae (15.1%). 75% of E Coli and 55% of Klebsiella Pneumoniae were Extended Spectrum Beta Lactamase (ESBL) producers. Cabapenem resistance was present in 8% of Klebsiella Pneumoniae isolates. Frequency of Vancomycin Resistant Enterococci (VRE) was 10%.

Conclusion:
High prevalence of resistance to various broad spectrum antibiotics needs to be considered while planning empirical antibiotic therapy in complicated intra-abdominal infections.